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Vaccine adjuvants

Tailor-made mast-cell granules

Mast cells induce protective immune responses through secretion of stimulatory granules. Microparticles modelled after mast-cell granules are now shown to replicate and enhance the functions of their natural counterparts and to direct the character of the resulting immunity.

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Figure 1: Natural versus synthetic mast-cell granules.


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Correspondence to Matthias Gunzer.

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The author declares no competing financial interests.

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Gunzer, M. Tailor-made mast-cell granules. Nature Mater 11, 181–182 (2012).

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