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Protein folding

To knot or not to knot?

Nature Materials volume 10, pages 84–86 (2011)Cite this article

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A knot-containing protein is found to fold reversibly at biologically relevant timescales despite not having naturally evolved for this ability.

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Figure 1: Knots in proteins.
Figure 2: Unknotted (top) and knotted (bottom) twin proteins.

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Authors and Affiliations

  1. Eugene Shakhnovich is at the Department of Chemistry, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA. shakhnovich@chemistry.harvard.edu,

    Eugene Shakhnovich

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  1. Eugene Shakhnovich
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Shakhnovich, E. To knot or not to knot?. Nature Mater 10, 84–86 (2011). https://doi.org/10.1038/nmat2953

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