Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Tissue engineering

Polymers flex their muscles

Accordion-like honeycomb scaffolds support the formation of anisotropically contracting heart tissue in vitro, opening up possibilities in the area of cardiac tissue repair.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The bilaminar PGS scaffold with an interconnected network of pores is suitable for the culture of neonatal rat heart cells.


  1. Stewart, S., MacIntyre, K., Hole, D. J., Capewell, S. & McMurray, J. J. Eur. J. Heart Fail. 3, 315–322 (2001).

    Article  CAS  Google Scholar 

  2. Zimmermann, W. H. et al. Cardiovasc. Res. 71, 419–429 (2006).

    Article  CAS  Google Scholar 

  3. Engelmayr, G. C. et al. Nature Mater. 7, 1003–1010 (2008).

    Article  CAS  Google Scholar 

  4. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  5. Park, I. H. et al. Nature 451, 141–146 (2008).

    Article  CAS  Google Scholar 

  6. Guan, K. et al. Nature 440, 1199–1203 (2006).

    Article  CAS  Google Scholar 

  7. Conrad, S. et al. Nature 10.1038/nature07404 (2008).

  8. Chen, Q. Z. et al. Biomaterials 29, 47–57 (2008).

    Article  Google Scholar 

  9. Wang, Y., Ameer, G. A., Sheppard, B. J. & Langer, R. Nature Biotechnol. 20, 602–606 (2002).

    Article  CAS  Google Scholar 

  10. Kocica, M. J. et al. Eur. J. Cardiothorac. Surg. 29 Suppl. 1, S21–40 (2006).

    Article  Google Scholar 

  11. Radisic, M. et al. Tissue Eng. 12, 2077–2091 (2006).

    Article  CAS  Google Scholar 

  12. Zimmermann, W. H. & Eschenhagen, T. Trends Cardiovasc. Med. 17, 134–40 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Zimmermann, WH. Polymers flex their muscles. Nature Mater 7, 932–933 (2008).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing