Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Drug delivery

The heart of the matter

Nature Materials volume 7, pages 836–837 (2008)Cite this article

A polymeric delivery vehicle, with neutral degradation products, keeps inflammation at bay during sustained drug release following myocardial infarction.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Drug release from a degradable matrix.
Figure 2: The embedded drug and matrix degradation products are released as the matrix erodes.

References

  1. Sy, J. C. et al. Nature Mater. 7, 863–869 (2008).

    Article  CAS  Google Scholar 

  2. Luman, N. R., Smeds, K. A. & Grinstaff, M. W. Chem. Eur. J. 9, 5618–5626 (2003).

    Article  CAS  Google Scholar 

  3. Richards Grayson, A. C. et al. Nature Mater. 2, 767–772 (2003).

    Article  Google Scholar 

  4. Tabata, Y., Gutta, S. & Langer, R. Pharm. Res. 10, 487–496 (1993).

    Article  CAS  Google Scholar 

  5. Wang, C. et al. Nature Mater. 3, 190–196 (2004).

    Article  CAS  Google Scholar 

  6. Zelikin, A. N., Zawaneh, P. N. & Putnam, D. Biomacromolecules 7, 3239–3244 (2006).

    Article  CAS  Google Scholar 

  7. Zawaneh, P. N., Doody, A. M., Zelikin, A. N. & Putnam, D. Biomacromolecules 7, 3245–3251 (2006).

    Article  CAS  Google Scholar 

  8. Heffernan, M. J. & Murthy, N. Bioconjug. Chem. 16, 1340–1342 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. David Putnam is in the Department of Biomedical Engineering and the School of Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Ithaca, New York 14853, USA. dap43@cornell.edu,

    David Putnam

Authors
  1. David Putnam
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Putnam, D. The heart of the matter. Nature Mater 7, 836–837 (2008). https://doi.org/10.1038/nmat2309

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmat2309

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing