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Contribution of hematopoietic stem cells to skeletal muscle

Nature Medicine volume 9, pages 15281532 (2003) | Download Citation

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Abstract

Cells from adult bone marrow participate in the regeneration of damaged skeletal myofibers. However, the relationship of these cells with the various hematopoietic and nonhematopoietic cell types found in bone marrow is still unclear. Here we show that the progeny of a single cell can both reconstitute the hematopoietic system and contribute to muscle regeneration. Integration of bone marrow cells into myofibers occurs spontaneously at low frequency and increases with muscle damage. Thus, classically defined single hematopoietic stem cells can give rise to both blood and muscle.

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Acknowledgements

We thank A. Johnson for help with flow cytometry, and R. Doyonnas, K. McNagny and M. Labarge for useful comments. T.R.B. was supported by a Lutheran Brotherhood Fellowship and by National Institutes of Health predoctoral training grant GM07149. H.M.B. was supported by NIH grants HD18179, HL65572, AG09521 and AG2096l, and by Ellison Foundation grant AG-SS-0817. F.M.V.R. is supported by a Canada Research Chair in Regenerative Medicine. This work was supported by Canadian Institutes of Health Research grant MOP-53332 and from the Networks of Centres of Excellence–Stem Cell Network Plasticity Project funding to F.M.V.R.

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Affiliations

  1. The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.

    • Stéphane Y Corbel
    • , Adrienne Lee
    • , Lin Yi
    • , Jeffrey Duenas
    •  & Fabio M V Rossi
  2. Baxter Laboratory in Genetic Pharmacology, Departments of Molecular Pharmacology and Microbiology and Immunology, Stanford University School of Medicine, CCSR4215, Stanford, California 94305, USA.

    • Timothy R Brazelton
    •  & Helen M Blau

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The authors declare no competing financial interests.

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Correspondence to Fabio M V Rossi.

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https://doi.org/10.1038/nm959

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