Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer

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  • A Corrigendum to this article was published on 11 October 2011

Abstract

Inhibition of the kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy.

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Figure 1: KSR1 inactivation prevents A431 tumorigenesis.
Figure 2: KSR antisense ODNs abrogate PANC-1 and A549 tumorigenesis.

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Acknowledgements

These studies were supported by National Institutes of Health grants CA42385 (R.K.) and CA52462 (Z.F.).

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Correspondence to Richard Kolesnick.

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The authors declare no competing financial interests.

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