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Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer

Nature Medicine volume 9, pages 1267–1268 (2003)Cite this article

A Corrigendum to this article was published on 11 October 2011

Abstract

Inhibition of the kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy.

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Figure 1: KSR1 inactivation prevents A431 tumorigenesis.
Figure 2: KSR antisense ODNs abrogate PANC-1 and A549 tumorigenesis.

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Acknowledgements

These studies were supported by National Institutes of Health grants CA42385 (R.K.) and CA52462 (Z.F.).

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Authors and Affiliations

  1. Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, New York, USA

    H Rosie Xing, Xinzhu Deng, Luis Campodonico & Richard Kolesnick

  2. Laboratory of Clinical Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, New York, USA

    William Tong

  3. Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, New York, USA

    Carlos Cordon-Cardo

  4. Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, New York, USA

    Zvi Fuks

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  1. H Rosie Xing
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  2. Carlos Cordon-Cardo
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  3. Xinzhu Deng
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  5. Luis Campodonico
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  7. Richard Kolesnick
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Correspondence to Richard Kolesnick.

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Xing, H., Cordon-Cardo, C., Deng, X. et al. Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nat Med 9, 1267–1268 (2003). https://doi.org/10.1038/nm927

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