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T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura


Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.

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Figure 1: Gene expression and fluorescence-activated cell sorting analysis of T cells from ITP patients.
Figure 2: Cell-mediated cytotoxicity against platelets in patients with active chronic ITP.

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  1. Harrington, W.J., Minnich V., Hollingsworth J.W. & Moore, J.C. J. Lab. Clin. Med. 38, 1–10 (1951).

    CAS  PubMed  Google Scholar 

  2. Cines, D.B. & Blanchette, V.S. N. Engl. J. Med. 346, 995–1008 (2002).

    Article  Google Scholar 

  3. Warner, M.N., Moore, J.C., Warkentin, T.E., Santos, A.V. & Kelton, J.G. Br. J. Haematol. 104, 442–447 (1999).

    Article  CAS  Google Scholar 

  4. Brighton, T.A., Evans, S., Castaldi, P.A., Chesterman, C.N. & Chong, B.H. Blood 88, 194–201 (1996).

    CAS  PubMed  Google Scholar 

  5. Semple, J.W. et al. Blood 87, 4245–4254 (1996).

    CAS  PubMed  Google Scholar 

  6. Hopkins, L., Davis, J., Schwartz, K. & Gerlach, J. Hum. Immunol. 63, S5 (2002).

  7. Vilches, C. & Parham, P. Annu. Rev. Immunol. 20, 217–251 (2002).

    Article  CAS  Google Scholar 

  8. Boyington, J.C., Brooks, A.G. & Sun, P.D. Immunol. Rev. 181, 66–78 (2001).

    Article  CAS  Google Scholar 

  9. Ozsoylu, S., Karabent, A., Irken, G. & Tuncer, M. Am. J. Hematol. 36, 82–85 (1991).

    Article  CAS  Google Scholar 

  10. Berchtold, P. & Wenger, M. Blood 81, 1246–1250 (1993).

    CAS  PubMed  Google Scholar 

  11. Imbach, P. et al. J. Pediatr. 118, 535–539 (1991).

    Article  CAS  Google Scholar 

  12. Stockelberg, D., Hou, M., Jacobsson, S., Kutti, J. & Wadenvik, H. Eur. J. Haematol. 56, 72–77 (1996).

    Article  CAS  Google Scholar 

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Grants were from the Swedish Medical Research Council (projects no. 11630, 11285 and 13141) and the IngaBritt and Arne Lundberg Forskningsstiftelse.

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Correspondence to Per-Ola Andersson.

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The authors declare no competing financial interests.

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Olsson, B., Andersson, PO., Jernås, M. et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 9, 1123–1124 (2003).

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