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Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells


Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t1/2 = 44 months) that eradication is unlikely.

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Figure 1: Extremely slow decay of the latent reservoir in patients on HAART.


  1. Gulick, R.M. et al. N. Engl. J. Med. 337, 734–739 (1997).

    CAS  Article  Google Scholar 

  2. Hammer, S.M. et al. N. Engl. J. Med. 337, 725–733 (1997).

    CAS  Article  Google Scholar 

  3. Perelson, A.S. et al. Nature 387, 188–191 (1997).

    CAS  Article  Google Scholar 

  4. Chun, T.-W. et al. Nat. Med. 1, 1284–1290 (1995).

    CAS  Article  Google Scholar 

  5. Chun, T.-W. et al. Nature 387, 183–188 (1997).

    CAS  Article  Google Scholar 

  6. Finzi, D. et al. Science 278, 1295–1300 (1997).

    CAS  Article  Google Scholar 

  7. Wong, J.K. et al. Science 278, 1291–1295 (1997).

    CAS  Article  Google Scholar 

  8. Chun, T.W. et al. Proc. Natl. Acad. Sci. USA 94, 13193–13197 (1997).

    CAS  Article  Google Scholar 

  9. Finzi, D. et al. Nat. Med. 5, 512–517 (1999).

    CAS  Article  Google Scholar 

  10. Blankson, J.N. Annu. Rev. Med. 53, 557–593 (2002).

    CAS  Article  Google Scholar 

  11. Zhang, L. et al. N. Engl. J. Med. 340, 1605–1613 (1999).

    CAS  Article  Google Scholar 

  12. Ramratnam, B. et al. Nat. Med. 6, 82–85 (2000).

    CAS  Article  Google Scholar 

  13. Dornadula, G. et al. JAMA 282, 1627–1632 (1999).

    CAS  Article  Google Scholar 

  14. Ruff, C.T. et al. J. Virol. 76, 9481–9492 (2002).

    CAS  Article  Google Scholar 

  15. Hermankova, M. et al. JAMA 286, 196–207 (2001).

    CAS  Article  Google Scholar 

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We thank S. Barnett for coordinating patient visits. This work was supported by National Institutes of Health grant AI43222 to R.F.S. and by a grant from the Doris Duke Charitable Foundation.

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Correspondence to Robert F Siliciano.

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Siliciano, J., Kajdas, J., Finzi, D. et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 9, 727–728 (2003).

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