Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS- associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8–infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8–specific T cells for the control of post-transplant KS.
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This study was supported by the Associazione Italiana per la Ricerca sul Cancro, Milan, Italy (M.L.). We thank G. Santagostino, R. Ricci, L. Bignardi, F. Cardarelli, A. Savazzi, G. Pizov and D. Rubinger for providing the KS biopsies and the clinical data from the renal transplant patients; G. Beduschi for contributing to the microsatellite analysis; and E. Cesarman for enlightening discussion.
The authors declare no competing financial interests.
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Barozzi, P., Luppi, M., Facchetti, F. et al. Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors. Nat Med 9, 554–561 (2003). https://doi.org/10.1038/nm862
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