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Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

Abstract

Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body–like inclusions that stained positively for α-synuclein and ubiquitin and to have reduced immunostaining for dopamine transporter. These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease.

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Figure 1: Long-term graft viability in Parkinson's disease.
Figure 2: Parkinson's disease–like pathology in long-term nigral grafts.

References

  1. Olanow, C.W. et al. Ann. Neurol. 54, 403–414 (2003).

    Article  Google Scholar 

  2. Freed, C.R. et al. N. Engl. J. Med. 344, 710–719 (2001).

    Article  CAS  Google Scholar 

  3. Sawle, G.V. et al. Ann. Neurol. 31, 166–173 (1992).

    Article  CAS  Google Scholar 

  4. Piccini, P. et al. Nat. Neurosci. 2, 1137–1140 (1999).

    Article  CAS  Google Scholar 

  5. Kordower, J.H. et al. N. Engl. J. Med. 332, 1118–1124 (1995).

    Article  CAS  Google Scholar 

  6. Kordower, J.H. et al. J. Comp. Neurol. 370, 203–230 (1996).

    Article  CAS  Google Scholar 

  7. Kordower, J.H. et al. Cell Transplant. 6, 213–219 (1997).

    Article  CAS  Google Scholar 

  8. Mendez, I. et al. Brain 128, 1498–1510 (2005).

    Article  Google Scholar 

  9. Braak, H. et al. Neurobiol. Aging 24, 197–211 (2003).

    Article  Google Scholar 

  10. Chu, Y. & Kordower, J.H. Neurobiol. Dis. 25, 134–149 (2007).

    Article  CAS  Google Scholar 

  11. Olanow, C.W. et al. Lancet Neurol. 3, 496–503 (2004).

    Article  Google Scholar 

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Acknowledgements

We would like to thank G. Folino for histological assistance.

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Authors and Affiliations

Authors

Contributions

J.H.K. and Y.C. performed the histological analysis. R.A.H. performed the clinical assessments. T.B.F. did brain ascertainment. J.H.K., R.A.H., T.B.F. and C.W.O. wrote the manuscript. C.W.O., T.B.F. and J.H.K. designed the original open label transplant trial. T.B.F. and C.W.O. implemented the original clinical transplant trial.

Corresponding author

Correspondence to Jeffrey H Kordower.

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Competing interests

J.H.K. is a consultant for Ceregene, Inc., Brainstorm, Inc. and Nupathe, Inc. C.W.O. is a consultant for Ceregene, Inc. These companies could benefit from the results of this study.

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Kordower, J., Chu, Y., Hauser, R. et al. Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 14, 504–506 (2008). https://doi.org/10.1038/nm1747

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