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The surprising rise of nonthrombogenic valvular surgery

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Figure 1: First (homemade) glutaraldehyde-treated pig valve implanted in human.
Figure 2: First- and second-generation bioprostheses.
Figure 3: A bioprosthesis compressed within a stent can be introduced percutaneously or through the apex of the beating heart.
Figure 4: Valve reconstruction.


  1. Gibbon, J.H. Jr. Application of a mechanical heart and lung apparatus to cardiac surgery. Minn. Med. 37, 171–185 (1954).

    PubMed  Google Scholar 

  2. Starr, A. & Edwards, M.L. Mitral replacement: clinical experience with a ball-valve prosthesis. Ann. Surg. 154, 726–740 (1961).

    Article  CAS  Google Scholar 

  3. Ross, D.N. Homograft replacement of the aortic valve. Lancet 2, 487 (1962).

    Article  CAS  Google Scholar 

  4. Binet, J.P., Carpentier, A., Langlois, J., Duran, C. & Colvez, P. Implantation de valves hétérogènes dans le traitement de cardiopathies aortiques. C. R. Acad. Sci. Hebd. Seances Acad. Sci. D 261, 5733–5734 (1965).

    CAS  PubMed  Google Scholar 

  5. Nageotte, J. Sur la greffe des tissus morts. C. R. Soc. Biol. (Paris) 1, 925–933 (1917).

    Google Scholar 

  6. Carpentier, A. et al. Mitral and tricuspid valve replacement with frame-mounted aortic heterografts. J. Thorac. Cardiovasc. Surg. 56, 388–394 (1968).

    CAS  PubMed  Google Scholar 

  7. Carpentier, A., Lemaigre, G., Robert, L., Carpentier, S. & Dubost, C. Biological factors affecting long-term results of valvular heterografts. J. Thorac. Cardiovasc. Surg. 58, 467–483 (1969).

    CAS  PubMed  Google Scholar 

  8. Magilligan, D.J. Jr., Lewis, J.W. Jr., Tilley, B. & Peterson, E. The porcine bioprosthetic valve. Twelve years later. J. Thorac. Cardiovasc. Surg. 89, 499–507 (1985).

    PubMed  Google Scholar 

  9. Carpentier, A., Nashef, A., Carpentier, S., Ahmed, A. & Goussef, N. Techniques for prevention of calcification of valvular bioprostheses. Circulation 70, I165–I168 (1984).

    Article  CAS  Google Scholar 

  10. Carpentier, S.M. et al. Heat treatment mitigates calcification of valvular bioprostheses. Ann. Thorac. Surg. 66, S264–S266 (1998).

    Article  CAS  Google Scholar 

  11. Khambadkone, S. et al. Percutaneous pulmonary valve implantation in humans: results in 59 consecutive patients. Circulation 112, 1189–1197 (2005).

    Article  Google Scholar 

  12. Carpentier, A. Cardiac valve surgery—the “French Correction”. J. Thorac. Cardiovasc. Surg. 86, 323–337 (1983).

    CAS  PubMed  Google Scholar 

  13. Braunberger, E. et al. Very long-term results (more than 20 years) of valve repair with Carpentier's techniques in nonrheumatic mitral valve insufficiency. Circulation 104, I8–I11 (2001).

    Article  CAS  Google Scholar 

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I would like to acknowledge my second family: the members of my research laboratory. As Diaghilev said to Nijinsky, I often tell them, “Surprise me!”, and they do it. I am proud to mention among others the seminal contributions of J.C. Chachques to dynamic cardiomyoplasty, P. Menasché to cell therapy, N. Lila to the study of HLA-G histocompatibility antigen expression in transplanted patients, and E. Martinod, who first showed the surprising metaplasia of an aorta into a true neo-trachea when implanted into the tracheal environment. My final words are to express my deep gratitude to the Lasker Foundation for the honor of being distinguished with such a highly prestigious award that I share with all the members of my laboratory and my department of cardiac surgery.

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Carpentier, A. The surprising rise of nonthrombogenic valvular surgery. Nat Med 13, 1165–1168 (2007).

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