(a) T cells inhibited induction of TNF-producing CD11b+ or CD11c+ cells and IFN-γ–producing NK cells in vitro. (b) Decreased inflammatory cytokines from innate cells (CD11b+ cells, NK cells or both) after poly(I:C) in the presence of T cells. (c) Mortality curve of control hIg–treated (⋄, n = 10) and TNFR–hIg–treated nude mice (▪, n = 5) after injection of 700 μg poly(I:C). (d) Mortality curve of Rag-1 knockout mice (hIg: ⋄, n = 5 and TNFR-hIg: ▪, n = 5) after poly(I:C) injection. (e) Decreased inflammatory cytokines from non-T cells after poly(I:C) stimulation and addition of soluble TNFR-hIg. (f) Mortality curve of Rag-1 knockout (⋄, n = 8) and NK-depleted Rag-1 knockout (▪, n = 8) mice. (g) Levels of proinflammatory cytokines in serum from Rag-1 knockout and NK-depleted (NK−) Rag-1 knockout mice were determined at 2 and 6 h after poly(I:C) injection. *P < 0.05, **P < 0.01, by t-test.