Figure 2: Wild-type mice are more resistant to poly(I:C) than nude mice and Rag-1 knockout mice, and T cells are essential for controlling proinflammatory cytokine production in vivo. | Nature Medicine

Figure 2: Wild-type mice are more resistant to poly(I:C) than nude mice and Rag-1 knockout mice, and T cells are essential for controlling proinflammatory cytokine production in vivo.

From: Adaptive immune cells temper initial innate responses

Figure 2

(a) Mortality curves of wild-type BALB/c (, n = 7) and nude mice (▪, n = 10) after injection with 700 μg poly(I:C). (b) TNF and IFN-γ concentrations in serum were determined at 2 h and 6 h after poly(I:C) injection (n = 4–9). (c) Mortality curves of wild-type C57BL6 (, n = 8) and Rag-1 knockout (▪, n = 16) mice after injection with 400 μg poly(I:C). (d) TNF and IFN-γ in serum of wild-type C57BL6 and Rag-1 knockout mice 2 h and 6 h after poly(I:C) injection. (e) TNF and IFN-γ in serum of T cell–depleted wild-type C57BL6 mice 2 h and 6 h after poly(I:C) injection. The results are representative of two experiments (n = 6 mice total, 3 per group). (f) Reduced cytokines in Rag-1 knockout mice reconstituted with lymphocytes. Rag-1 knockout mice (n = 4 per group) were adoptively transferred with lymphocytes for 2 d and then treated with poly(I:C); reconstituted mice produced significantly lower levels of cytokines than control mice. *P < 0.05, by t-test.

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