The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1. NOTE: We are retracting this report as it contains several errors, including duplications and manipulations of some flow cytometry plots in Figure 1a and in Supplementary Figure 2 online, incorrect juxtaposition of data in Figure 1g (spleen) that in fact derive from different experiments, and inaccurate reporting of the absolute number of iNKT cells and s.d. values, even though the statistical significance remains unchanged. Although original data exist for each figure that largely support the conclusions drawn, we believe that the number of figures affected means that the appropriate response is to retract this paper.
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We thank R. Brutkiewicz and K. Hayakawa for the gifts of NKT cell lines, L. Peltonen for providing the initial Aire−/− mice and Kirin Brewery Pharmaceutical Co. for α-GalCer. We acknowledge H. He for his assistance with artwork. This work was supported in part by grants from the American Diabetes Association (to Q.-S.M.), the Juvenile Diabetes Research Foundation International (to Q.-S.M.), the US National Institutes of Health (to J.-X.S.) and the Canadian Institutes of Health Research (to T.L.D.).
The authors declare no competing financial interests.
The number of iNKT cells is reduced in NOD. Aire-deficient mice. (PDF 134 kb)
Percentages of CD4, CD8, iNKT and NK cells in Aire-deficient mice. (PDF 1100 kb)
Autoantibodies in bone marrow recipient mice. (PDF 627 kb)
Gene expression analyzed by quantitative RT-PCR. (PDF 539 kb)
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Mi, QS., Deng, ZB., Joshi, S. et al. The autoimmune regulator (Aire) controls iNKT cell development and maturation. Nat Med 12, 624–626 (2006). https://doi.org/10.1038/nm1424
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