AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis

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Abstract

An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.

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Figure 1: Effect of HLA alleles on different stages of AIDS progression.

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Acknowledgements

This study has been funded in part with federal funds from the US National Cancer Institute (NCI), US National Institutes of Health (NIH), under Contract No. NO1-CO-12400, the US National Institute on Drug Abuse (DA 04334), and by the Intramural Research Program of the NIH, NCI, Center for Cancer Research. We wish to thank P. Goulder and C. O'hUigin for helpful discussions. The study was approved by the Protocol Review Office of the NCI institutional review board. Informed consent was obtained at the study sites from all individuals.

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Correspondence to Mary Carrington.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Table 1

Effect of HLA class I alleles on AIDS progression in 1,089 seroconverters. (PDF 17 kb)

Supplementary Methods (PDF 81 kb)

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Gao, X., Bashirova, A., Iversen, A. et al. AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis. Nat Med 11, 1290–1292 (2005) doi:10.1038/nm1333

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