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Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

Nature Medicine volume 11, pages 1293–1294 (2005)Cite this article

Abstract

Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.

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Figure 1: Plasma viral load in SHIV-162P3-infected animals.

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Author notes

  1. Ronald S Veazey and Martin S Springer: These authors contributed equally to this work.

Authors and Affiliations

  1. Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, 70433, Louisiana, USA

    Ronald S Veazey, Preston A Marx & Jason Dufour

  2. Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, 07065, New Jersey, USA

    Martin S Springer

  3. Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, W-805, New York, 10021, New York, USA

    Per Johan Klasse & John P Moore

Authors
  1. Ronald S Veazey
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  2. Martin S Springer
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  3. Preston A Marx
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  4. Jason Dufour
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  5. Per Johan Klasse
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  6. John P Moore
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Corresponding author

Correspondence to John P Moore.

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Competing interests

Martin S. Springer is an employee of Merck Inc., but this company did not fund the study.

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Veazey, R., Springer, M., Marx, P. et al. Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor. Nat Med 11, 1293–1294 (2005). https://doi.org/10.1038/nm1321

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