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NOS knockouts and neuroprotection

Nature Medicine volume 5, pages 1354–1355 (1999)Cite this article

Abstract

Neuronal nitric oxide synthase (nNOS) is known to be involved in the dopaminergic neurodegeneration that occurs in the MPTP model of Parkinson disease. Recent studies indicate that different isoforms of NOS may act synergistically to cause neuronal injury in Parkinson disease and other neurodegenerative diseases (1403–1409).

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Figure 1: Putative contribution of iNOS and nNOS to cell death in the MPTP model of Parkinson's disease.

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Authors and Affiliations

  1. Department of Neurology New York Presbyterian Hospital Cornell University, 525 East 68th Street, New York City, 10021, New York, USA

    Thomas Grünewald & M. Flint Beal

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  1. Thomas Grünewald
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  2. M. Flint Beal
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Grünewald, T., Beal, M. NOS knockouts and neuroprotection. Nat Med 5, 1354–1355 (1999). https://doi.org/10.1038/70918

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