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NOS knockouts and neuroprotection


Neuronal nitric oxide synthase (nNOS) is known to be involved in the dopaminergic neurodegeneration that occurs in the MPTP model of Parkinson disease. Recent studies indicate that different isoforms of NOS may act synergistically to cause neuronal injury in Parkinson disease and other neurodegenerative diseases (1403–1409).

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Figure 1: Putative contribution of iNOS and nNOS to cell death in the MPTP model of Parkinson's disease.


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Grünewald, T., Beal, M. NOS knockouts and neuroprotection. Nat Med 5, 1354–1355 (1999).

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