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Fashioning drugs for stroke

The interaction between two proteins associated with a glutamate receptor can drive neuronal death mediated through this receptor after stroke. A small molecule, designed to specifically disrupt this deadly interaction, protects the brain in mice and rats against neuronal damage without undesirable side effects (pages 1439–1443).

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Figure 1: The rationalized design of a small molecule that disrupts the neuronal death complex NR2B–PSD-95–nNOS to prevent damage after stroke.

Marina Corral

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Correspondence to Yu Tian Wang.

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Lai, T., Wang, Y. Fashioning drugs for stroke. Nat Med 16, 1376–1378 (2010). https://doi.org/10.1038/nm1210-1376

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