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Crippling SWI-SNF makes tumors GLI-ful

The chromatin remodeling complex SWI-SNF is altered in cancer. New findings now show that the core component SNF5 can block a Hedgehog (Hh) effector, which promotes malignant rhabdoid tumor growth when SNF5 is lost (pages 1429–1433). Targeting this Hh effector may be a way to combat these aggressive childhood tumors.

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Figure 1: Loss of SNF5 allows misexpression of GLI1 in MRT.

Marina Corral


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Correspondence to Jeremy F Reiter.

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Reiter, J. Crippling SWI-SNF makes tumors GLI-ful. Nat Med 16, 1374–1376 (2010).

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