Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Crippling SWI-SNF makes tumors GLI-ful

The chromatin remodeling complex SWI-SNF is altered in cancer. New findings now show that the core component SNF5 can block a Hedgehog (Hh) effector, which promotes malignant rhabdoid tumor growth when SNF5 is lost (pages 1429–1433). Targeting this Hh effector may be a way to combat these aggressive childhood tumors.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Loss of SNF5 allows misexpression of GLI1 in MRT.

Marina Corral

References

  1. Tamkun, J.W. et al. Cell 68, 561–572 (1992).

    Article  CAS  Google Scholar 

  2. Versteege, I. et al. Nature 394, 203–206 (1998).

    Article  CAS  Google Scholar 

  3. Lee, D. et al. J. Biol. Chem. 277, 22330–22337 (2002).

    Article  CAS  Google Scholar 

  4. Cheng, S.W. et al. Nat. Genet. 22, 102–105 (1999).

    Article  CAS  Google Scholar 

  5. Roberts, C.W., Galusha, S.A., McMenamin, M.E., Fletcher, C.D. & Orkin, S.H. Proc. Natl. Acad. Sci. USA 97, 13796–13800 (2000).

    Article  CAS  Google Scholar 

  6. Zhang, Z.K. et al. Mol. Cell. Biol. 22, 5975–5988 (2002).

    Article  CAS  Google Scholar 

  7. Gresh, L. et al. EMBO J. 24, 3313–3324 (2005).

    Article  CAS  Google Scholar 

  8. Jagani, Z. et al. Nat. Med. 16, 1429–1433 (2010).

    Article  CAS  Google Scholar 

  9. Nilsson, M. et al. Proc. Natl. Acad. Sci. USA 97, 3438–3443 (2000).

    Article  CAS  Google Scholar 

  10. Dahmane, N., Lee, J., Robins, P., Heller, P. & Ruiz i Altaba, A. Nature 389, 876–881 (1997).

    Article  CAS  Google Scholar 

  11. Park, H.L. et al. Development 127, 1593–1605 (2000).

    CAS  PubMed  Google Scholar 

  12. Isaacs, H. Jr. J. Pediatr. Surg. 45, 619–626 (2010).

    Article  Google Scholar 

  13. Simone, C. et al. Nat. Genet. 36, 738–743 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jeremy F Reiter.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Reiter, J. Crippling SWI-SNF makes tumors GLI-ful. Nat Med 16, 1374–1376 (2010). https://doi.org/10.1038/nm1210-1374

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1210-1374

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer