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Beyond TGF-β: a prostaglandin promotes fibrosis

Nature Medicine volume 15, pages 13601361 (2009) | Download Citation

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The deposition of excess scar tissue that occurs in lung fibrosis is known to be mediated by transforming growth factor-β (TGF-β). Prostaglandin F and the F prostanoid (FP) receptor are now identified as mediators that act independently of TGF-β (pages 1426–1430).

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Author information

Affiliations

  1. Mitchell A. Olman is in the Department of Pathobiology, Lerner Research Institute and Respiratory Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

    • Mitchell A Olman

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Correspondence to Mitchell A Olman.

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https://doi.org/10.1038/nm1209-1360

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