Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Quelling cholesterol pathway fends off brain damage

A molecular pathway known for regulating cholesterol and lipid metabolism is now implicated in stroke (pages 1399–1406). The pathway is bumped up by N-methyl-D-aspartate glutamate receptors (NMDARs), which are hyperactivated in stroke and other conditions.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: NMDAR-mediated activation of SREBP in neuronal cells.

Kim Caesar

References

  1. Papadia, S. & Hardingham, G.E. Neuroscientist 13, 572–579 (2007).

    Article  CAS  Google Scholar 

  2. Taghibiglou, C. et al. Nat. Med. 15, 1399–1406 (2009).

    Article  CAS  Google Scholar 

  3. Bengoechea-Alonso, M.T. & Ericsson, J. Curr. Opin. Cell Biol. 19, 215–222 (2007).

    Article  CAS  Google Scholar 

  4. Ferré, P. & Foufelle, F. Horm. Res. 68, 72–82 (2007).

    PubMed  Google Scholar 

  5. Goldstein, J.L., Debose-Boyd, R.A. & Brown, M.S. Cell 124, 35–46 (2006).

    Article  CAS  Google Scholar 

  6. Lee, J.N. & Ye, J. J. Biol. Chem. 279, 45257–45265 (2004).

    Article  CAS  Google Scholar 

  7. Bengoechea-Alonso, M.T. & Ericsson, J. Cdk1/. Cell Cycle 5, 1708–1718 (2006).

    Article  CAS  Google Scholar 

  8. Kamisuki, S. et al. Chem. Biol. 16, 882–892 (2009).

    Article  CAS  Google Scholar 

  9. Iwasaki, Y. et al. Biochem. Biophys. Res. Commun. 378, 545–550 (2009).

    Article  CAS  Google Scholar 

  10. Gibot, L. et al. Biochem. J. 420, 473–483 (2009).

    Article  CAS  Google Scholar 

  11. Wang, X., Sato, R., Brown, M.S., Hua, X. & Goldstein, J.L. Cell 77, 53–62 (1994).

    Article  CAS  Google Scholar 

  12. Muir, K.W. Curr. Opin. Pharmacol. 6, 53–60 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Johan Ericsson.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bengoechea-Alonso, M., Ericsson, J. Quelling cholesterol pathway fends off brain damage. Nat Med 15, 1358–1359 (2009). https://doi.org/10.1038/nm1209-1358

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1209-1358

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing