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Atherosclerosis: keep your macrophages in shape

Lipid accumulation leads to atherosclerosis partly by eliciting lethal levels of cellular stress in macrophages. A signaling pathway that drives such lipid-induced toxicity is now identified. The findings reveal a chaperoning function that might provide the clue needed to rescue this pathogenic effect (pages 1383–1391).

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Figure 1: A lipid-sensing pathway in macrophages links aP2 to toxic lipid–induced ER stress in the development of atherosclerosis.

Marina Corral


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Correspondence to James M Ntambi.

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Liu, X., Ntambi, J. Atherosclerosis: keep your macrophages in shape. Nat Med 15, 1357–1358 (2009).

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