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Atherosclerosis: keep your macrophages in shape

Lipid accumulation leads to atherosclerosis partly by eliciting lethal levels of cellular stress in macrophages. A signaling pathway that drives such lipid-induced toxicity is now identified. The findings reveal a chaperoning function that might provide the clue needed to rescue this pathogenic effect (pages 1383–1391).

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Figure 1: A lipid-sensing pathway in macrophages links aP2 to toxic lipid–induced ER stress in the development of atherosclerosis.

Marina Corral

References

  1. Lloyd-Jones, D. et al. Circulation 119, 480–486 (2009).

    Article  Google Scholar 

  2. Finn, A.V., Kramer, M.C., Vorpahl, M., Kolodgie, F.D. & Virmani, R. Expert Opin. Pharmacother. 10, 1587–1603 (2009).

    CAS  Article  Google Scholar 

  3. Erbay, E. et al. Nat. Med. 15, 1383–1391 (2009).

    CAS  Article  Google Scholar 

  4. Furuhashi, M. & Hotamisligil, G.S. Nat. Rev. Drug Discov. 7, 489–503 (2008).

    CAS  Article  Google Scholar 

  5. Zhou, J., Lhotak, S., Hilditch, B.A. & Austin, R.C. Circulation 111, 1814–1821 (2005).

    CAS  Article  Google Scholar 

  6. Myoishi, M. et al. Circulation 116, 1226–1233 (2007).

    Article  Google Scholar 

  7. Feng, B. et al. Nat. Cell Biol. 5, 781–792 (2003).

    CAS  Article  Google Scholar 

  8. Borradaile, N.M. et al. J. Lipid Res. 47, 2726–2737 (2006).

    CAS  Article  Google Scholar 

  9. Makowski, L. et al. Nat. Med. 7, 699–705 (2001).

    CAS  Article  Google Scholar 

  10. Flowers, M.T., Miyazaki, M., Liu, X. & Ntambi, J.M. J. Clin. Invest. 116, 1478–1481 (2006).

    CAS  Article  Google Scholar 

  11. MacDonald, M.L. et al. Arterioscler. Thromb. Vasc. Biol. 29, 341–347 (2009).

    CAS  Article  Google Scholar 

  12. Brown, J.M. et al. Circulation 118, 1467–1475 (2008).

    CAS  Article  Google Scholar 

  13. Savransky, V. et al. Circ. Res. 103, 1173–1180 (2008).

    CAS  Article  Google Scholar 

  14. Smith, J.A. et al. Eur. J. Immunol. 38, 1194–1203 (2008).

    CAS  Article  Google Scholar 

Download references

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Correspondence to James M Ntambi.

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Liu, X., Ntambi, J. Atherosclerosis: keep your macrophages in shape. Nat Med 15, 1357–1358 (2009). https://doi.org/10.1038/nm1209-1357

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  • DOI: https://doi.org/10.1038/nm1209-1357

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