Lipid accumulation leads to atherosclerosis partly by eliciting lethal levels of cellular stress in macrophages. A signaling pathway that drives such lipid-induced toxicity is now identified. The findings reveal a chaperoning function that might provide the clue needed to rescue this pathogenic effect (pages 1383–1391).
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References
Lloyd-Jones, D. et al. Circulation 119, 480–486 (2009).
Finn, A.V., Kramer, M.C., Vorpahl, M., Kolodgie, F.D. & Virmani, R. Expert Opin. Pharmacother. 10, 1587–1603 (2009).
Erbay, E. et al. Nat. Med. 15, 1383–1391 (2009).
Furuhashi, M. & Hotamisligil, G.S. Nat. Rev. Drug Discov. 7, 489–503 (2008).
Zhou, J., Lhotak, S., Hilditch, B.A. & Austin, R.C. Circulation 111, 1814–1821 (2005).
Myoishi, M. et al. Circulation 116, 1226–1233 (2007).
Feng, B. et al. Nat. Cell Biol. 5, 781–792 (2003).
Borradaile, N.M. et al. J. Lipid Res. 47, 2726–2737 (2006).
Makowski, L. et al. Nat. Med. 7, 699–705 (2001).
Flowers, M.T., Miyazaki, M., Liu, X. & Ntambi, J.M. J. Clin. Invest. 116, 1478–1481 (2006).
MacDonald, M.L. et al. Arterioscler. Thromb. Vasc. Biol. 29, 341–347 (2009).
Brown, J.M. et al. Circulation 118, 1467–1475 (2008).
Savransky, V. et al. Circ. Res. 103, 1173–1180 (2008).
Smith, J.A. et al. Eur. J. Immunol. 38, 1194–1203 (2008).
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Liu, X., Ntambi, J. Atherosclerosis: keep your macrophages in shape. Nat Med 15, 1357–1358 (2009). https://doi.org/10.1038/nm1209-1357
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DOI: https://doi.org/10.1038/nm1209-1357
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