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Memantine strikes the perfect balance

Nature Medicine volume 15, pages 13551356 (2009) | Download Citation

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Excessive stimulation of glutamate receptors results in excitotoxicity and has a role in a variety of neurodegenerative disorders, including Huntington's disease. By blocking pathological extrasynaptic activity but preserving normal synaptic function, the N-methyl-D-aspartic acid (NMDA) receptor antagonist memantine—at the proper dosage—emerges as a potential treatment for such neurological disorders (pages 1407–1413).

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Affiliations

  1. Albert R. La Spada is in the Divisions of Genetics, Pediatrics and Cellular & Molecular Medicine and the Institute for Genomic Medicine, University of California–San Diego–Rady Children's Hospital, La Jolla, California, USA.

    • Albert R La Spada

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Correspondence to Albert R La Spada.

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https://doi.org/10.1038/nm1209-1355

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