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Memantine strikes the perfect balance

Excessive stimulation of glutamate receptors results in excitotoxicity and has a role in a variety of neurodegenerative disorders, including Huntington's disease. By blocking pathological extrasynaptic activity but preserving normal synaptic function, the N-methyl-D-aspartic acid (NMDA) receptor antagonist memantine—at the proper dosage—emerges as a potential treatment for such neurological disorders (pages 1407–1413).

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Figure 1: Model for memantine modulation of synaptic activity in Huntington's disease therapy.

Kim Caesar

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Correspondence to Albert R La Spada.

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La Spada, A. Memantine strikes the perfect balance. Nat Med 15, 1355–1356 (2009). https://doi.org/10.1038/nm1209-1355

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