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Targeting RAS and PI3K in lung cancer

The phosphoinositide 3-kinase (PI3K) and RAS oncoproteins are activated in many major tumor types and control linked signaling pathways. An inhibitor of PI3K is now shown to shrink tumors in transgenic mouse cancer models. The drug also blocks RAS-induced lung tumors when combined with an inhibitor of mitogen-activated protein kinase kinase (pages 1351–1356).

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Figure 1: The Ras and PI3K signaling pathways.

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Downward, J. Targeting RAS and PI3K in lung cancer. Nat Med 14, 1315–1316 (2008). https://doi.org/10.1038/nm1208-1315

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  • DOI: https://doi.org/10.1038/nm1208-1315

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