Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Targeting RAS and PI3K in lung cancer

The phosphoinositide 3-kinase (PI3K) and RAS oncoproteins are activated in many major tumor types and control linked signaling pathways. An inhibitor of PI3K is now shown to shrink tumors in transgenic mouse cancer models. The drug also blocks RAS-induced lung tumors when combined with an inhibitor of mitogen-activated protein kinase kinase (pages 1351–1356).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: The Ras and PI3K signaling pathways.


  1. Downward, J. Nat. Rev. Cancer 3, 11–22 (2003).

    Article  CAS  Google Scholar 

  2. Marone, R., Cmiljanovic, V., Giese, B. & Wymann, M.P. Biochim. Biophys. Acta 1784, 159–185 (2008).

    Article  CAS  Google Scholar 

  3. Engelman, J.A. et al. Nat. Med. 14, 1351–1356 (2008).

    Article  CAS  Google Scholar 

  4. Samuels, Y. et al. Science 304, 554 (2004).

    Article  CAS  Google Scholar 

  5. Maira, S.M. et al. Mol. Cancer Ther. 7, 1851–1863 (2008).

    Article  CAS  Google Scholar 

  6. Gupta, S. et al. Cell 129, 957–968 (2007).

    Article  CAS  Google Scholar 

  7. Lim, K.H. & Counter, C.M. Cancer Cell 8, 381–392 (2005).

    Article  CAS  Google Scholar 

  8. Davies, B.R. et al. Mol. Cancer Ther. 6, 2209–2219 (2007).

    Article  CAS  Google Scholar 

  9. Hingorani, S.R. et al. Cancer Cell 4, 437–450 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Downward, J. Targeting RAS and PI3K in lung cancer. Nat Med 14, 1315–1316 (2008).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing