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Incapacitating the immune system in cystic fibrosis

Phagocytes swarm to the lung in individuals with cystic fibrosis but are unable to clear infection. A close examination of neutrophil biology reveals that Pseudomonas aeruginosa in the lung disables these phagocytes, which then turn on each other (pages 1423–1430).

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Figure 1: Disruption of innate immunity by Pseudomonas aeruginosa.

Kim Caesar


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Sabroe, I., Whyte, M. Incapacitating the immune system in cystic fibrosis. Nat Med 13, 1417–1418 (2007).

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