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Putting the heat on cancer

Nature Medicine volume 13, pages 1415–1417 (2007)Cite this article

Two studies highlight the role of the heat shock response in initiating and maintaining cancer.

The heat shock response is an ancient and evolutionarily conserved mechanism orchestrated by the transcription factor heat shock factor-1 (HSF1). The main job of HSF1 is to regulate the induction of molecular chaperones and other heat shock proteins—permitting cell survival under stressful, protein-damaging conditions.

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Figure 1: HSP90 and HSF1 regulate tumor cell survival.

Kim Caesar

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Authors and Affiliations

  1. Paul Workman and Emmanuel de Billy are in the Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK paul.workman@icr.ac.uk,

    Paul Workman & Emmanuel de Billy

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  1. Paul Workman
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  2. Emmanuel de Billy
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Competing interests

P.W. has developed HSP90 inhibitors that are licensed to Vernalis and Novartis. He has received research funding from Vernalis and is a consultant to Novartis.

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Workman, P., de Billy, E. Putting the heat on cancer. Nat Med 13, 1415–1417 (2007). https://doi.org/10.1038/nm1207-1415

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