Adoptive T cell transfer studies in mice and in cancer patients have shown substantial potential, but also major barriers, for successful therapeutic outcomes. A new strategy may overcome some of these barriers. T cells can now be engineered with 'autocostimulation' properties along with chimeric receptors specific for tumor antigens (pages 1440–1449).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Kim Caesar
References
Greenberg, P.D., Cheever, M.A. & Fefer, A. J. Exp. Med. 154, 952–963 (1981).
Ho, W.Y., Blattman, J.N., Dossett, M.L., Yee, C. & Greenberg, P.D. Cancer Cell 3, 431–437 (2003).
Yee, C. et al. Proc. Natl. Acad. Sci. USA 99, 16168–16173 (2002).
Dudley, M.E. et al. Science 298, 850–854 (2002).
Stephan, M.T. et al. Nat. Med. 13, 1440–1449 (2007).
Kessels, H.W., Wolkers, M.C., van den Boom, M.D., van der Valk, M.A. & Schumacher, T.N. Nat. Immunol. 2, 957–961 (2001).
Holler, P.D. et al. Proc. Natl. Acad. Sci. USA 97, 5387–5392 (2000).
Kuball, J. et al. Immunity 22, 117–129 (2005).
Gross, G., Waks, T. & Eshhar, Z. Proc. Natl. Acad. Sci. USA 86, 10024–10028 (1989).
Greenwald, R.J., Freeman, G.J. & Sharpe, A.H. Annu. Rev. Immunol. 23, 515–548 (2005).
Watts, T.H. Annu. Rev. Immunol. 23, 23–68 (2005).
Morgan, R.A. et al. Science 314, 126–129 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pardoll, D. Building the bionic T cell. Nat Med 13, 1411–1413 (2007). https://doi.org/10.1038/nm1207-1411
Issue Date:
DOI: https://doi.org/10.1038/nm1207-1411
