Activation of certain G protein–coupled receptors stimulates production of the neurotoxic amyloid-β peptide through internalization of a membrane-embedded protease (pages 1390–1396).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tanzi, R.E. & Bertram, L. Cell 120, 545–555 (2005).
Hardy, J. & Selkoe, D.J. Science 297, 353–356 (2002).
Ni, Y. et al. Nat. Med. 12, 1390–1396 (2006).
Wolfe, M.S. Curr. Top. Dev. Biol. 54, 233–261 (2003).
Wolfe, M.S. Nat. Rev. Drug Discov. 1, 859–866 (2002).
Runz, H. et al. J. Neurosci. 22, 1679–1689 (2002).
Caccamo, A. et al. Neuron 49, 671–682 (2006).
Koo, E.H. & Squazzo, S.L. J. Biol. Chem. 269, 17386–17389 (1994).
Walsh, D.M. et al. Nature 416, 535–539 (2002).
Kopan, R. & Ilagan, M.X. Nat. Rev. Mol. Cell Biol. 5, 499–504 (2004).
Lazarov, O. et al. Cell 120, 701–713 (2005).
Lim, G.P. et al. J. Neurosci. 25, 3032–3040 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wolfe, M. Alzheimer protease hitches a ride. Nat Med 12, 1352–1353 (2006). https://doi.org/10.1038/nm1206-1352
Issue Date:
DOI: https://doi.org/10.1038/nm1206-1352