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Alzheimer protease hitches a ride

Activation of certain G protein–coupled receptors stimulates production of the neurotoxic amyloid-β peptide through internalization of a membrane-embedded protease (pages 13901396).

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Figure 1: Receptor-mediated endocytosis of γ-secretase.

Kim Caesar

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Wolfe, M. Alzheimer protease hitches a ride. Nat Med 12, 1352–1353 (2006). https://doi.org/10.1038/nm1206-1352

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