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Savior and slayer: the two faces of p53

Low levels of DNA damage caused by oxidative stress can be repaired, whereas extensive damage usually results in cell death. p53 contributes to both outcomes by stimulating expression of either pro- or antioxidant genes (pages 1306–1313).

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Figure 1: p53 has both pro- and antioxidant functions.

Katie Ris

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Bensaad, K., Vousden, K. Savior and slayer: the two faces of p53. Nat Med 11, 1278–1279 (2005). https://doi.org/10.1038/nm1205-1278

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