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More neurons, less weight

Nature Medicine volume 11, pages 1276–1278 (2005)Cite this article

Treatment with a neuronal growth factor stimulates weight loss—and spurs the development of new neurons that help maintain reduced weight.

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Figure 1: CNTF triggers weight loss and neurogenesis.

Katie Ris

References

  1. Ettinger, M.P. et al. JAMA 289, 1826–1832 (2003).

    Article  CAS  Google Scholar 

  2. Lambert, P.D. et al. Proc. Natl. Acad. Sci. USA 98, 4652–4657 (2001).

    Article  CAS  Google Scholar 

  3. Kokoeva, M.V., Yin, H. & Flier, J.S. Science 310, 679–683 (2005).

    Article  CAS  Google Scholar 

  4. Seeley, R.J. & Woods, S.C. Nat. Rev. Neurosci. 4, 901–909 (2003).

    Article  CAS  Google Scholar 

  5. Ahima, R.S. Trends Endocrinol. Metab. 16, 307–313 (2005).

    Article  CAS  Google Scholar 

  6. Bluher, S. et al. Diabetes 53, 2787–2796 (2004).

    Article  Google Scholar 

  7. Farooqi, I.S. et al. N. Engl. J. Med. 341, 913–915 (1999).

    Article  Google Scholar 

  8. Halaas, J.L. et al. Science 269, 543–546 (1995).

    Article  CAS  Google Scholar 

  9. Seeley, R.J., Drazen, D.L. & Clegg, D.J. Annu. Rev. Nutr. 24, 133–149 (2004).

    Article  CAS  Google Scholar 

  10. Bouret, S.G., Draper, S.J. & Simerly, R.B. Science 304, 108–110 (2004).

    Article  CAS  Google Scholar 

  11. Pinto, S. et al. Science 304, 110–115 (2004).

    Article  CAS  Google Scholar 

  12. Gropp, E. et al. Nat. Neurosci. 8, 1289–1291 (2005).

    Article  CAS  Google Scholar 

  13. Luquet, S., Perez, F.A., Hnasko, T.S. & Palmiter, R.D. Science 310, 683–685 (2005).

    Article  CAS  Google Scholar 

  14. Munzberg, H., Flier, J.S. & Bjorbaek, C. Endocrinology 145, 4880–4889 (2004).

    Article  Google Scholar 

Download references

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  1. Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, 45237, Ohio, USA

    Randy J Seeley

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  1. Randy J Seeley
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Seeley, R. More neurons, less weight. Nat Med 11, 1276–1278 (2005). https://doi.org/10.1038/nm1205-1276

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