Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

More neurons, less weight

Treatment with a neuronal growth factor stimulates weight loss—and spurs the development of new neurons that help maintain reduced weight.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: CNTF triggers weight loss and neurogenesis.

Katie Ris


  1. Ettinger, M.P. et al. JAMA 289, 1826–1832 (2003).

    Article  CAS  Google Scholar 

  2. Lambert, P.D. et al. Proc. Natl. Acad. Sci. USA 98, 4652–4657 (2001).

    Article  CAS  Google Scholar 

  3. Kokoeva, M.V., Yin, H. & Flier, J.S. Science 310, 679–683 (2005).

    Article  CAS  Google Scholar 

  4. Seeley, R.J. & Woods, S.C. Nat. Rev. Neurosci. 4, 901–909 (2003).

    Article  CAS  Google Scholar 

  5. Ahima, R.S. Trends Endocrinol. Metab. 16, 307–313 (2005).

    Article  CAS  Google Scholar 

  6. Bluher, S. et al. Diabetes 53, 2787–2796 (2004).

    Article  Google Scholar 

  7. Farooqi, I.S. et al. N. Engl. J. Med. 341, 913–915 (1999).

    Article  Google Scholar 

  8. Halaas, J.L. et al. Science 269, 543–546 (1995).

    Article  CAS  Google Scholar 

  9. Seeley, R.J., Drazen, D.L. & Clegg, D.J. Annu. Rev. Nutr. 24, 133–149 (2004).

    Article  CAS  Google Scholar 

  10. Bouret, S.G., Draper, S.J. & Simerly, R.B. Science 304, 108–110 (2004).

    Article  CAS  Google Scholar 

  11. Pinto, S. et al. Science 304, 110–115 (2004).

    Article  CAS  Google Scholar 

  12. Gropp, E. et al. Nat. Neurosci. 8, 1289–1291 (2005).

    Article  CAS  Google Scholar 

  13. Luquet, S., Perez, F.A., Hnasko, T.S. & Palmiter, R.D. Science 310, 683–685 (2005).

    Article  CAS  Google Scholar 

  14. Munzberg, H., Flier, J.S. & Bjorbaek, C. Endocrinology 145, 4880–4889 (2004).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Seeley, R. More neurons, less weight. Nat Med 11, 1276–1278 (2005).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing