Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Chipping away at gallstones

Gallstones develop in response to an imbalance of lipids in bile, the digestive fluid produced in the liver. A compound that restores the balance prevents gallstone formation in mouse models (pages 1352–1358).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Manufacturing a gallstone.

References

  1. Moschetta, A., Bookout, A.L. & Mangelsdorf, D.J. Nat. Med. 10, 1352–1358 (2004).

    Article  CAS  Google Scholar 

  2. Heuman, D., Wassef, W. & Vlahcevic, Z. in Shiff's Diseases of the Liver (eds. Shiff, E.R., Sorrell, M.F. & Maddrey, W.C.) 631–645 (Lippincott-Raven, Philadelphia, 1999).

    Google Scholar 

  3. Sinal, C.J. et al. Cell 102, 731–744 (2000).

    Article  CAS  Google Scholar 

  4. Makishima, M. et al. Science 284, 1362–1355 (1999).

    Article  CAS  Google Scholar 

  5. Parks, D.J. et al. Science 284, 1365–1368 (1999).

    Article  CAS  Google Scholar 

  6. Wittenburg, H. et al. Gastroenterology 125, 868–881 (2003).

    Article  CAS  Google Scholar 

  7. Maloney, P.R. et al. J. Med. Chem. 43, 2971–2974 (2000).

    Article  CAS  Google Scholar 

  8. Chen, F. et al. Gastroenterology 126, 756–764 (2004).

    Article  CAS  Google Scholar 

  9. Konikoff, F.M. MedGenMed 5, 8 (2003).

    PubMed  Google Scholar 

  10. Gerloff, T. et al. J. Biol. Chem. 273, 10046–10050 (1998).

    Article  CAS  Google Scholar 

  11. Yu, L. et al. Proc. Natl. Acad. Sci. USA 99, 16237–16242 (2002).

    Article  CAS  Google Scholar 

  12. Smit, J.J. et al. Cell 75, 451–462 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Goralski, K., Sinal, C. Chipping away at gallstones. Nat Med 10, 1301–1302 (2004). https://doi.org/10.1038/nm1204-1301

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1204-1301

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing