Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Vitamin A helps gut T cells find their way in the dark

Once activated, some T cells home to distinct sites in the body, such as the intestine and inflamed skin. Research in mice shows that dendritic cells in the gut produce a derivative of vitamin A, retinoic acid, that gives T cells directions.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Retinoic acid–induced acquisition of gut-homing molecules during T-cell activation.

Ann Thomson

Figure 2: T cells in the intestinal mucosa.

Reprinted with permission from Cell Press

References

  1. Iwata, M. et al. Immunity. 21, 527–538 (2004).

    Article  CAS  Google Scholar 

  2. Campbell, D.J. et al. J. Exp. Med. 195, 135–141 (2002).

    Article  CAS  Google Scholar 

  3. Svensson, M. et al. J. Clin. Invest. 110, 1113–1121 (2002).

    Article  CAS  Google Scholar 

  4. Stagg, A.J. et al. Eur. J. Immunol. 32, 1445–1454 (2002).

    Article  CAS  Google Scholar 

  5. Mora, J.R. et al. Nature. 424, 88–93 (2003).

    Article  CAS  Google Scholar 

  6. Johansson-Lindbom, B. et al. J. Exp. Med. 198, 963–969 (2003).

    Article  CAS  Google Scholar 

  7. Andrew, D.P. et al. Eur. J. Immunol. 26, 897–905 (1996).

    Article  CAS  Google Scholar 

  8. Cheroutre, H. Annu. Rev. Immunol. 22, 217–246 (2004).

    CAS  Google Scholar 

  9. Duester, G. Eur.J. Biohem 267, 4315–4324 (2000).

    Article  CAS  Google Scholar 

  10. Malmstrom, V. et al. J. Immunol. 166, 6972–6981 (2001).

    Article  CAS  Google Scholar 

  11. Zhang, C. et al. Dermatol. Ther. 16, 322–330 (2003).

    Article  Google Scholar 

  12. Driscoll, H.K. Metabolism 45, 248–253 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Johansson-Lindbom, B., Agace, W. Vitamin A helps gut T cells find their way in the dark. Nat Med 10, 1300–1301 (2004). https://doi.org/10.1038/nm1204-1300

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1204-1300

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing