Combination stroke therapy: easy as APC?

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The US Food and Drug Administration has approved only one therapy for ischemic stroke, recombinant tissue plasminogen activator (tPA), which can increase blood flow to damaged brain tissue—but it can also have severe side effects and must be administered shortly after stroke. Experiments combining the drug with activated protein C (APC) may provide a solution (pages 1379–1383).

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Figure 1: Two-stroke approach to stroke.

Deborah Maizels

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Lo, E. Combination stroke therapy: easy as APC?. Nat Med 10, 1295–1296 (2004) doi:10.1038/nm1204-1295

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