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Ion implicated in blood pact

Nature Medicine volume 9, pages 1460–1461 (2003)Cite this article

Nitric oxide has achieved fame as a regulator of numerous physiological processes, far outshining its humbler cousins, nitrate and nitrite. Now, nitrite steps into the spotlight. It appears that this ion may provide a source of NO during the regulation of blood flow under stressful conditions (pages 1498–1505).

The radical nitric oxide (NO) is a high-profile molecule that regulates a wide variety of physiological functions, ranging from modulating neurotransmission to combating pathogens and cancer. One of its most important functions is the management of blood flow, which it does by inducing vasodilation.

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Figure 1: Nitrite chemistry in tissue.

References

  1. Cosby, K. et al. Nat. Med. 1498–1505 (2003).

  2. Brizel, D.M. et al. Radiother. Oncol. 53, 113–117 (1999).

    CAS  Article  Google Scholar 

  3. Rodriguez, J. et al. Proc. Natl. Acad. Sci. USA 100, 336–341 (2003).

    CAS  Article  Google Scholar 

  4. Rassaf, T. et al. Nat. Med. 5, 481–482 (2003).

    Article  Google Scholar 

  5. Zumft, W.G. Microbiol. Mol. Biol. Rev. 61, 533–616 (1997).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Zhang, Z. et al. Biochem. Biophys. Res. Comm. 249, 767–772 (1998).

    CAS  Article  Google Scholar 

  7. Bolli, R. J. Mol. Cell. Cardiol. 33, 1897–1918 (2001).

    CAS  Article  Google Scholar 

  8. Klebanoff, S.J. Free Radic. Biol. Med. 14, 351–360 (1993).

    CAS  Article  Google Scholar 

  9. Eiserich, J.P. et al. Nature 391, 393–397 (1998).

    CAS  Article  Google Scholar 

  10. Thomas, D.D. et al. Proc. Natl. Acad. Sci. USA 99, 12691–12696 (2002).

    CAS  Article  Google Scholar 

  11. Kotamraju, S. et al. Proc. Natl. Acad. Sci. USA 100, 10653–10658 (2003).

    CAS  Article  Google Scholar 

  12. Souza, J.M. et al. J. Biol. Chem. 275, 18344–18349 (2000).

    CAS  Article  Google Scholar 

Download references

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  1. Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, 20892, Maryland, USA

    David A Wink

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  1. David A Wink
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Wink, D. Ion implicated in blood pact. Nat Med 9, 1460–1461 (2003). https://doi.org/10.1038/nm1203-1460

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  • DOI: https://doi.org/10.1038/nm1203-1460

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