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The great escape – AIDS viruses and immune control

Abstract

Many studies have been designed to address the role of CTL immune escape in HIV-1 infection, but have not given conclusive answers. Now, an elegant longitudinal analysis clearly demonstrates that progression to disease in SIV-infected macaques is associated with evasion of the CTL response (pages 1270–1276).

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Figure 1: Left, the frequency of HIV/SIV escape mutations are likely to vary with the effectiveness of the CTL response.

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Goulder, P., Walker, B. The great escape – AIDS viruses and immune control. Nat Med 5, 1233–1235 (1999). https://doi.org/10.1038/15184

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