Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The pros and cons of drug ‘trafficking’

Internalization of targeted therapeutics is often needed for efficacy, but also alters drug penetration of a tissue. A new model explores the trade-offs of intracellular drug trafficking.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Ghetie, M.A. & Vitetta, E.S. Recent developments in immunotoxin therapy. Curr. Opin. Immunol. 6, 707–714 (1994).

    Article  CAS  Google Scholar 

  2. Gene therapeutics: Methods and applications of direct gene transfer, (ed. Wolff, J.A.) (Birkhaüser, Boston, 1994).

  3. Juweid, M. et al. Micropharmacology of monoclonal antibodies in solid tumors: Direct evidence for a binding site barrier. Cancer Res. 52, 5144–5153 (1992).

    CAS  PubMed  Google Scholar 

  4. Sung, C., Dedrick, R.L., Hall, W.A., Johnson, P.A. & Youle, R.J. The spatial distribution of immunotoxins in solid tumors: Assessment by quantitative autoradiography. Cancer Res. 53, 2092–2099 (1993).

    CAS  PubMed  Google Scholar 

  5. Shockley, T.R. et al. Spatial distribution of tumor-specific monoclonal antibodies in human melanoma xenografts. Cancer Res. 52, 367–376 (1992).

    CAS  PubMed  Google Scholar 

  6. Fujimori, K., Covell, D.G., Fletcher, J.E. & Weinstein, J.N. Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab′)2, and Fab in tumors. Cancer Res. 49, 5656–5663 (1989).

    CAS  PubMed  Google Scholar 

  7. Rippley, R.K. & Stokes, C.L. Effects of cellular pharmacology on drug distribution in tissues. Biophys. J. 69, 825–839 (1995).

    Article  CAS  Google Scholar 

  8. Yazdi, P.T. & Murphy, R.M. Quantitative analysis of protein synthesis inhibition by transferrin-toxin conjugates. Cancer Res. 54, 6387–6394 (1994).

    CAS  PubMed  Google Scholar 

  9. Vijaykumar, V. & Topp, E.M. Diffusion of an anti-transferrin receptor antibody in cultured murine melanoma cell layers. Pharmaceutical Research (in the press).

  10. Myrdal, S. & Foster, M. Time-resolved confocal analysis of antibody penetration into living, solid tumor spheroids. Scanning 16, 155–167 (1994).

    Article  CAS  Google Scholar 

  11. Lauffenburger, D.A. & Linderman, J.J. Receptors: Models for Binding, Trafficking and Signaling (Oxford Univ. Press, New York, 1993).

    Google Scholar 

  12. Baxter, L.T., Yuan, F. & Jain, R.K. Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: Comparison with experimental data. Cancer Res. 52, 5838–5844 (1992).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stokes, C. The pros and cons of drug ‘trafficking’. Nat Med 1, 1135–1136 (1995). https://doi.org/10.1038/nm1195-1135

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1195-1135

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing