Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

The state of the art in antisense research

Antisense development has required diligent efforts by many labs to allow it to progress. Improved methods have helped to transgress many barriers, resulting in a vibrant technology geared towards generating new human therapuetics.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Zamecnik, P.C. & Stephenson, M.L. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. natn. Acad. Sci. U.S.A. 75, 280–284 (1978).

    Article  CAS  Google Scholar 

  2. Stein, C.A. & Krieg, A.M. Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides. Antisense Res. Dev. 4, 67–69 (1994).

    Article  CAS  Google Scholar 

  3. Wagner, R.W. Gene inhibition using anti-sense oligodeoxynucleotides. Nature 372, 333–335 (1994).

    Article  CAS  Google Scholar 

  4. Wagner, R.W. et al. Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science 260, 1510–1513 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wagner, R. The state of the art in antisense research. Nat Med 1, 1116–1118 (1995). https://doi.org/10.1038/nm1195-1116

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1195-1116

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing