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An unSIRTain role in longevity

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References

  1. Tissenbaum, H.A. & Guarente, L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227–230 (2001).

    Article  CAS  PubMed  Google Scholar 

  2. Rogina, B. & Helfand, S. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101, 15998–16003 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Burnett, C. et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477, 482–485 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Viswanathan, M. & Guarente, L. Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 477, E1–E2 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Taguchi, A., Wartschow, L.M. & White, M.F. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369–372 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Blüher, M., Kahn, B.B. & Kahn, C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572–574 (2003).

    Article  PubMed  Google Scholar 

  7. Bauer, J.H. et al. dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster. Aging (Albany NY) 1, 38–48 (2009).

    Article  CAS  Google Scholar 

  8. Satoh, A, Stein, L, Imai, S. The role of mammalian sirtuins in the regulation of metabolism, aging and longevity. Handb. Exp. Pharmacol. 206, 125–162 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kaeberlein, M., McVey, M. & Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570–2580 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Canto, C. & Auwerx, J. Don't write sirtuins off. Nature 477, 411 (2011).

    Google Scholar 

  11. Berdichevsky, A., Viswanathan, M., Horvitz, H.R. & Guarente, L. C. elegans SIR-2.1 interacts with 14–3-3 proteins to activate DAF-16 and extend life span. Cell 125, 1165–1177 (2006).

    Article  CAS  PubMed  Google Scholar 

  12. Viswanathan, M., Kim, S.K., Berdichevsky, A. & Guarente, L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 9, 605–615 (2005).

    Article  CAS  PubMed  Google Scholar 

  13. Rizki, G. et al. The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet. 7, e1002235 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Competing interests

D.A.S. is a consultant to GlaxoSmithKline, a company developing medicines that modulate sirtuins.

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An unSIRTain role in longevity. Nat Med 17, 1350–1351 (2011). https://doi.org/10.1038/nm1111-1350

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