Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Bitter treats for better breathing

A new study in mice and human tissue shows that activation of bitter taste receptors in the airways relaxes airway smooth muscle, resulting in bronchodilation (pages 1299–1304). Agonists of these receptors seem to be better than current β2-adrenergic bronchodilators in a mouse asthma model, suggesting a new way to ease breathing during asthma.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Bitter tastants induce bronchodilation in a mouse model of asthma.

Marina Corral

References

  1. Bai, Y. & Sanderson, M.J. Respir. Res. 7, 34 (2006).

    Article  Google Scholar 

  2. Somlyo, A.P. & Somlyo, A.V. Physiol. Rev. 83, 1325–1358 (2003).

    Article  CAS  Google Scholar 

  3. Bai, Y. & Sanderson, M.J. Am. J. Physiol. Lung Cell. Mol. Physiol. 296, L947–L958 (2009).

    Article  CAS  Google Scholar 

  4. Deshpande, D.A. et al. Nat. Med. 16, 1299–1304 (2010).

    Article  CAS  Google Scholar 

  5. Shah, A.S., Ben-Shahar, Y., Moninger, T.O., Kline, J.N. & Welsh, M.J. Science 325, 1131–1134 (2009).

    Article  CAS  Google Scholar 

  6. Sanderson, M.J., Delmotte, P., Bai, Y. & Perez-Zogbhi, J.F. Proc. Am. Thorac. Soc. 5, 23–31 (2008).

    Article  CAS  Google Scholar 

  7. Nelson, M.T. et al. Science 270, 633–637 (1995).

    Article  CAS  Google Scholar 

  8. Bootman, M.D., Berridge, M.J. & Lipp, P. Cell 91, 367–373 (1997).

    Article  CAS  Google Scholar 

  9. ZhuGe, R., Bao, R., Fogarty, K.E. & Lifshitz, L.M. J. Biol. Chem. 285, 2203–2210 (2010).

    Article  CAS  Google Scholar 

  10. Bai, Y. & Sanderson, M.J. Am. J. Physiol. Lung Cell. Mol. Physiol. 291, L208–L221 (2006).

    Article  CAS  Google Scholar 

  11. Delmotte, P. & Sanderson, M.J. Am. J. Respir. Cell Mol. Biol. 42, 373–381 (2010).

    Article  CAS  Google Scholar 

  12. Liu, C., Zuo, J., Pertens, E., Helli, P.B. & Janssen, L.J. Am. J. Physiol. Lung Cell. Mol. Physiol. 289, L574–L582 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J Mark Madison.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sanderson, M., Madison, J. Bitter treats for better breathing. Nat Med 16, 1190–1191 (2010). https://doi.org/10.1038/nm1110-1190

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1110-1190

This article is cited by

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research