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Autophagy thwarts muscle disease

Nature Medicine volume 16, pages 1188–1190 (2010)Cite this article

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Skeletal muscles in a mouse model of human muscular dystrophy degenerate because of excessive cell death. A new study suggests that these muscles suffer from lack of autophagy, exacerbating apoptosis and mitochondrial dysfunction (pages 1313–1320). Reactivation of autophagy with a low-protein diet may ameliorate muscle myopathy.

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Figure 1: Defective autophagy in the muscles of Col6a1-deficient mice leads to accumulation of dysfunctional mitochondria and muscle myopathy.

Marina Corral

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  1. Aviva M. Tolkovsky is at the Cambridge Centre for Brain Repair, Cambridge, UK.,

    Aviva M Tolkovsky

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  1. Aviva M Tolkovsky
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Correspondence to Aviva M Tolkovsky.

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Tolkovsky, A. Autophagy thwarts muscle disease. Nat Med 16, 1188–1190 (2010). https://doi.org/10.1038/nm1110-1188

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