Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Keep the 'phospho' on MAPK, be happy

Nature Medicine volume 16, pages 1187–1188 (2010)Cite this article

Subjects

Depression ruins the lives of millions of people, causing dysphoria and anguish. New findings in rodents and human brain shed light on the mechanisms of this disease, uncovering a phosphatase as a new target to treat depressive behaviors (pages 1328–1332).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The serine-threonine phosphatase MKP-1 is a key control point in the neurobiology of depression.

Marina Corral

References

  1. Moussavi, S. et al. Lancet 370, 851–858 (2007).

    Article  Google Scholar 

  2. Price, J.L. & Drevets, W.C. Neuropsychopharmacology 35, 192–216 (2010).

    Article  Google Scholar 

  3. Berton, O. & Nestler, E.J. Nat. Rev. Neurosci. 7, 137–151 (2006).

    Article  CAS  Google Scholar 

  4. Duric, V. et al. Nat. Med. 16, 1328–1332 (2010).

    Article  CAS  Google Scholar 

  5. Keyse, S.M. & Emslie, E.A. Nature 359, 644–647 (1992).

    Article  CAS  Google Scholar 

  6. Sun, H. et al. Cell 75, 487–493 (1993).

    Article  CAS  Google Scholar 

  7. Morrison, D.K. & Davis, R.J. Annu. Rev. Cell Dev. Biol. 19, 91–118 (2003).

    Article  CAS  Google Scholar 

  8. Jeffrey, K.L. et al. Nat. Rev. Drug Discov. 6, 391–403 (2007).

    Article  CAS  Google Scholar 

  9. Li, H., Zhang, L. & Huang, Q. Behav. Brain Res. 205, 32–37 (2009).

    Article  CAS  Google Scholar 

  10. Breitwieser, W. et al. Genes Dev. 21, 2069–2082 (2007).

    Article  CAS  Google Scholar 

  11. Czéh, B. et al. Neuropsychopharmacology 31, 1616–1626 (2006).

    Article  Google Scholar 

  12. Wu, J.J. et al. Cell Metab. 4, 61–73 (2006).

    Article  CAS  Google Scholar 

  13. Carlson, J. et al. Am. J. Pathol. 175, 1564–1573 (2009).

    Article  CAS  Google Scholar 

  14. Cizza, G., Primma, S. & Csako, G. Trends Endocrinol. Metab. 20, 367–373 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Schahram Akbarian is in the Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA,

    Schahram Akbarian

  2. Roger J. Davis is in the Program in Molecular Medicine, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA.,

    Roger J Davis

Authors
  1. Schahram Akbarian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roger J Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Schahram Akbarian or Roger J Davis.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Akbarian, S., Davis, R. Keep the 'phospho' on MAPK, be happy. Nat Med 16, 1187–1188 (2010). https://doi.org/10.1038/nm1110-1187

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1110-1187

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research