Overexpression of T cell leukemia homeobox 1 (TLX1) occurs in some leukemias. New findings in mice and humans show how TLX1 drives chromosomal aberrations and deletions of tumor suppressor genes during T-cell transformation (pages 1321–1327). Surprisingly, its expression does not correlate with bad prognosis.
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Marina Corral
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Hoang, T., Hoang, T. The T-ALL paradox in cancer. Nat Med 16, 1185–1186 (2010). https://doi.org/10.1038/nm1110-1185
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DOI: https://doi.org/10.1038/nm1110-1185
