Overexpression of T cell leukemia homeobox 1 (TLX1) occurs in some leukemias. New findings in mice and humans show how TLX1 drives chromosomal aberrations and deletions of tumor suppressor genes during T-cell transformation (pages 1321–1327). Surprisingly, its expression does not correlate with bad prognosis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Marina Corral
References
Tremblay, C.S. & Hoang, T. Prog. Mol. Biol. Transl. Sci. 92, 121–156 (2010).
Van Vlierberghe, P., Pieters, R., Beverloo, H.B. & Meijerink, J.P. Br. J. Haematol. 143, 153–168 (2008).
Ford, A.M. et al. Proc. Natl. Acad. Sci. USA 95, 4584–4588 (1998).
De Keersmaecker, K. et al. Nat. Med. 16, 1321–1327 (2010).
Hawley, R.G. et al. Cancer Res. 57, 337–345 (1997).
Chen, E. et al. Oncogene 25, 2575–2587 (2006).
Ferrando, A.A. et al. Cancer Cell 1, 75–87 (2002).
Ikawa, T. et al. Science 329, 93–96 (2010).
Li, L., Leid, M. & Rothenberg, E.V. Science 329, 89–93 (2010).
Brown, M. et al. Cold Spring Harb. Symp. Quant. Biol. 56, 359–365 (1991).
Kawabe, T., Muslin, A.J. & Korsmeyer, S.J. Nature 385, 454–458 (1997).
McCormack, M.P. et al. Science 327, 879–883 (2010).
Tremblay, M. et al. Genes Dev. 24, 1093–1105 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Hoang, T., Hoang, T. The T-ALL paradox in cancer. Nat Med 16, 1185–1186 (2010). https://doi.org/10.1038/nm1110-1185
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm1110-1185
