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Attacking the flu: Neutralizing antibodies may lead to 'universal' vaccine

Nature Medicine volume 15, pages 12511252 (2009) | Download Citation

Flu remains a major killer because of imperfect vaccines and widespread resistance to existing antivirals—problems particularly acute during a pandemic. New findings at the bedside and at the bench could lead to improvements on both fronts. Grace Chen and Kanta Subbarao discuss the implications of research identifying human antibodies than can neutralize a range of viral subtypes. The findings may help lead to a 'universal' vaccine against these diverse and rapidly evolving viruses. Estanislao Nistal-Villán and Adolfo García-Sastre examine two recent studies that reveal the crystal structure of a promising viral drug target, the unique endonuclease domain of the viral polymerase. The findings open the door to the rational design of new influenza virus inhibitors.

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Affiliations

  1. Grace L. Chen and Kanta Subbarao are in the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA.

    • Grace L Chen
    •  & Kanta Subbarao

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Correspondence to Kanta Subbarao.

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DOI

https://doi.org/10.1038/nm1109-1251

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