Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Eye vessels saved by rescuing their pericyte partners

Nature Medicine volume 15, pages 1248–1249 (2009)Cite this article

High blood sugar can lead to diabetic retinopathy and subsequent blindness. Glucose is now found to quench a growth factor that keeps pericytes alive. Without these key support cells, the retinal vasculature degenerates (pages 1298–1306).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Interactions between endothelial cells and pericytes in the eye.

Marina Corral

References

  1. Klein, R. in Contemporary Diabetes: Diabetic Retinopathy (ed. Duh, E.) 67–107 (Humana Press, Totowa, New Jersey, 2008).

    Book  Google Scholar 

  2. National Diabetes Information Clearinghouse. http://diabetes.niddk.nih.gov/DM/pubs/statistics/DM_Statistics.pdf (2008).

  3. Geraldes, P. et al. Nat. Med. 15, 1298–1306 (2009).

    Article  CAS  Google Scholar 

  4. Aiello, L.P. et al. N. Engl. J. Med. 331, 1480–1487 (1994).

    Article  CAS  Google Scholar 

  5. Harhaj, N.S. et al. Invest. Ophthalmol. Vis. Sci. 47, 5106–5115 (2006).

    Article  Google Scholar 

  6. Murakami, T., Felinski, E.A. & Antonetti, D.A. J. Biol. Chem. 284, 21036–21046 (2009).

    Article  CAS  Google Scholar 

  7. Ishii, H. et al. Science 272, 728–731 (1996).

    Article  CAS  Google Scholar 

  8. Xia, P. et al. J. Clin. Invest. 98, 2018–2026 (1996).

    Article  CAS  Google Scholar 

  9. Aiello, L.P. et al. Ophthalmology 113, 2221–2230 (2006).

    Article  Google Scholar 

  10. Enge, M. et al. EMBO J. 21, 4307–4316 (2002).

    Article  CAS  Google Scholar 

  11. Dubois, M.J. et al. Nat. Med. 12, 549–556 (2006).

    Article  CAS  Google Scholar 

  12. Cogan, D.G., Toussaint, D. & Kuwabara, T. Arch. Ophthalmol. 66, 366–378 (1961).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. David Antonetti is at the Department of Cellular and Molecular Physiology and Ophthalmology, Penn State College of Medicine Hershey, PA USA.,

    David Antonetti

Authors
  1. David Antonetti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David Antonetti.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Antonetti, D. Eye vessels saved by rescuing their pericyte partners. Nat Med 15, 1248–1249 (2009). https://doi.org/10.1038/nm1109-1248

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1109-1248

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing