Autoimmunity: apoptotic fats grease transcription

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Transcription factors known for handling the body's response to lipids promote clearance of apoptotic cells by macrophages, according to new research (pages 1266–1272). When this process goes awry, autoimmunity can result.

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Figure 1: Disposing of the dead.

Marina Corral

References

  1. 1

    Ravichandran, K.S. & Lorenz, U. Nat. Rev. Immunol. 7, 964–974 (2007).

  2. 2

    Mukundan, L. et al. Nat. Med. 15, 1266–1272 (2009).

  3. 3

    A-Gonzalez, N. et al. Immunity 31, 245–258 (2009).

  4. 4

    Bensinger, S.J. & Tontonoz, P. Nature 454, 470–477 (2008).

  5. 5

    Evans, R.M., Barish, G.D. & Wang, Y.X. Nat. Med. 10, 355–361 (2004).

  6. 6

    Lemke, G. & Rothlin, C.V. Nat. Rev. Immunol. 8, 327–336 (2008).

  7. 7

    Erwig, L.P. & Henson, P.M. Am. J. Pathol. 171, 2–8 (2007).

  8. 8

    Kim, S., Elkon, K.B. & Ma, X. Immunity 21, 643–653 (2004).

  9. 9

    Bensinger, S.J. et al. Cell 134, 97–111 (2008).

  10. 10

    Manzi, S. et al. Am. J. Epidemiol. 145, 408–415 (1997).

  11. 11

    Kagan, V.E. et al. J. Immunol. 169, 487–499 (2002).

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Correspondence to Keith B Elkon.

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