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Sepsis: the dark side of histones

Nature Medicine volume 15, pages 12451246 (2009) | Download Citation

Injection of activated protein C (APC) is the last resort to rescue a patient with severe sepsis. Research into how APC works reveals that the drug inactivates histones (pages 1318–1321), which are toxic during severe sepsis.

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Author information

Affiliations

  1. Catherine Chaput and Arturo Zychlinsky are in the Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.

    • Catherine Chaput
    •  & Arturo Zychlinsky

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Correspondence to Arturo Zychlinsky.

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DOI

https://doi.org/10.1038/nm1109-1245

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