Injection of activated protein C (APC) is the last resort to rescue a patient with severe sepsis. Research into how APC works reveals that the drug inactivates histones (pages 1318–1321), which are toxic during severe sepsis.
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Chaput, C., Zychlinsky, A. Sepsis: the dark side of histones. Nat Med 15, 1245–1246 (2009). https://doi.org/10.1038/nm1109-1245
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DOI: https://doi.org/10.1038/nm1109-1245
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